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Mentor Reflections

It is amazing to have the opportunity to work with both Dr. Wagner and Mrs. Sparwasser in the creation of my Capstone project. Both of these individuals hold a wealth of knowledge that I have been happy to learn from in their respective fields. 

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Mrs. Sparwasser has been an invaluable individual during the creative process of my presentations and my spring action event. She has been there for me before each speech and has given me many pointers on how to simplify a complex scientific topic for an audience who may not have as much experience in the field. I have gained a multitude of presentation skills from her and she is a great person to come to for a confidence boost. Mrs. Sparwasser has been a fantastic individual to work with and I am immensely thankful that I have had the opportunity to work with her as a mentor.

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Through my work with Dr. Daniel Wagner, I have learned so much about my topic and have thanked him for the opportunity that he provided in the form of an internship and project to work on that coincided with my studies. Originally, my topic was leaning towards the study of angiogenesis, but after the first meeting with Dr. Wagner, I had decided that I enjoyed his topic just as much and saw it as an opportunity to get some real experience in a lab environment. So far, professor Wagner has been a great person to come to with questions and has been solid in helping me organize my research and find new papers and research to look over. He has given me many opportunities, from the internship to the opportunity to tour the Anderson Biology building labs at Rice, and everything he has done has been a great supplement to my current learning.

Overall Reflection

September Reflection

December/January Reflection

November Reflection

October Reflection

I met with Mrs. Sparwasser the day of my first speech in class. With her I discussed the bare minimum of my topic and was able to have the opportunity to run through my presentation once with her before I had to give it sixth period. This was extremely helpful to be able to run through the presentation before I had to give it because she gave me some valuable pointers on what things could be cut or simplified in order to give my speech in the limited amount of time. She also pointed out some things about my topic that could be explained in simpler terms so that people without much of a biology background could understand the main points. She also pointed out something that I hadn’t even thought of, that the growth of blood vessels is very similar to the growth of the plant root system. Both are activated by a change in specific chemical concentration and involve elongating certain cells and proliferation of cells in the tips of the spots of growth. She also gave me some insight that will help me move forward in my capstone project by helping me finalize my ideas on switching topics. She said that the new opportunity that my mentor was able to offer up to me would be much better in preparing me for college and encouraged me to pursue this new line of study.

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My meeting with Dr. Wagner was September the 22nd on the Rice Campus. Here I was able to meet with Dr. Wagner in his own personal office where I explained what I hoped to gain out of this project and also explained that I would like any opportunity that he has available to intern and work in his lab. After I gave a brief explanation of all of these things and he explained his job as well as the experiments that he was performing, he offered me the opportunity to work on a new project that he was starting up on schistosomiasis and snails. He got into pretty direct detail about the role of his studies in transgenic species and developmental biology. The meeting that I was able to have with Dr. Wagner made me think about the alternatives that he offered up to me and caused me to really think about what I hoped to gain from the experience of capstone. From his opportunity I thought about the new benefits that he explained to me and thought that this would be a much better opportunity for me in the fact that it offers me valuable experience in the production of my own experiments and research papers that would have the potential to be published. He described the specifics of the things that I would be able to work on that included the breeding of my own snails at my home in order to find the most optimum way for them to breed and the best way to collect their eggs so that we can perform the necessary gene replacements to create transgenic species and explained that he would guide me in the discovery of similar genes in the genome of the snail to the genomes of mice, humans, and zebrafish. Later on next week he offered up the opportunity to meet again where he would teach me the basics of navigating genome databases and locating similarities in the codes of different animals. I know that the new path he offered up to me will be much more beneficial in the long run and is actually a very interesting project that would allow me to gain much more practical experience than just plain research with angiogenesis.

I met with my off campus mentor very early in the month, right around the first week of the period. When I traveled down to Rice to meet with him, our goals for this meeting were to create an outline of what I would be doing and to introduce me to the laboratories and experiments that my research might help on. After making the  arduous journey downtown in rush hour traffic, I arrived to the Anderson biology building to meet with Dr. Wagner.

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When I first entered his office I had a few questions about the reading that he had given me from a textbook the last time we had met up. I asked my questions and showed him some of my notes, him giving me the best information possible as a response, until I had exhausted all of my questioning capacity and he began to ask questions of his own. He asked me about what I hope to get out of this project and whether or not I really wanted to partake in this activity and divert all of the knowledge I had already acquired on angiogenesis to the back of my brain. I then told him that the opportunity that he was giving me to work on hands on research and project design would be more valuable than the simple things that I could learn on paper about angiogenesis.

After I spoke a bit more candidly about what I wanted to do for my project he began to teach me all the things I would need to know about navigating a gene database and understanding why I was doing this and what purpose the research would have. He told me, after going through the many many steps involved in finding genes and protein patterns across species, that the goal of this understanding and tracking of genes in the NF-kB pathway would be to eventually make phylogenetic trees that sort the tested animals depending on whether or not they have the same genes and proteins as well as applications for those genes and proteins. All of this made perfect sense to me and I was sent off to begin working on the research aspect of the project in the gene databases. This process is a very arduous one that takes up so much of my time, but I know that it will definitely be worth it in the end to have made a contribution to the research that is stopping this disease that affects hundreds of millions of people all around the globe. I hope this is the first step into the biotechnology that I want to pursue as both a college degree and future career.

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Much later in the month I had my October meeting with my in school mentor Mrs. Sparwasser. Again, I had the great fortune of meeting with her on the day of my presentation so she was very helpful in giving me tips on where I should elaborate in my speech. She also gave me a boost of confidence for my performance and overall was a very encouraging soul to have around at this stressful time. As I was speaking with her she mentioned that her father had done some work on the disease Schistosomiasis back in the 80’s, and even if she didn’t remember much about it, she said she would try to dig up some information on his old projects.

This month I had two shorter meeting with my mentors than I have in the past, both were also later in the month due to everyone's commitments with Thanksgiving break. I had my in school mentor meeting first with Mrs. Sparwasser. Here I explained a bit more about the research I am working on and how these genetic comparisons are working and what they are working for. She showed genuine interest in it and asked me to bring in my spreadsheets at a later date to check out the process that has changed quite a bit since she was in school. I also ran my ideas for my spring action plan by her and she seemed to think that it would work, but put an emphasis on the fact that we would need to really bring the research we have completed down in difficulty so that it is easier for the children to understand. She told me to keep her posted and show her some of our plans for games and activities for our carts. I also asked her about the DNA lab we do as freshmen where we extract our DNA out of our cheek cells. What this lab entails is taking a swab of the cheek and placing it in a chemical solution that is safe for human skin contact. The next step is to agitate the liquid to the point where DNA strands start to show as thin white strings. This experiment, if we can get the funding, would be amazing to have because it would give the kids a visual representation of the tiny things we are talking about and it would also let them take something home where they would be able to remember and perhaps recall what they had learned. She recommended that I look at possible grants, talk to the museum to see if they would consider funding that side of the experiment, and definitely look up any liability rules that may be necessary.

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I also spoke with my off campus mentor Dr. Daniel Wagner this month. He gave me very insightful information about the experiment I am performing for him. Currently, I am working on my spreadsheets of data for the study of Biomphalaria glabrata comparative genomes and as I was making progress, I had many questions arise that went beyond my traditional questions of how to do something. I asked about the relationship with the yakuba type fly and the melanogaster fly as one protein was only showing matches under yakuba, but the two are so evolutionarily similar to one another, so I was wondering if it would be possible to interchange them. He told me that in this one instance it would be fine. It would need to be recorded as a gene from a different fly though, but he understood that we might be able to extrapolate that an immune trait was not the evolutionary factor that divided these guys at their common ancestors. I asked him several other questions pertaining to the experiment and some of the notation that is used in the databases that I was unfamiliar with, and for each question he gave me concise and clear examples as to why those things were the way they were.

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Overall, the mentor meetings for this month were a success and I appreciate meeting with both of these intelligent people to get feedback on my ideas for my work and spring action plan.

Coming Soon!

February Reflection

Coming Soon!

March Reflection

Coming Soon!

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